ABSTRACT
Aims: To estimate fasting plasma glucose (FPG), serum ferritin, HbA1c and serum nitric oxide levels in type 2 diabetes mellitus (DM) subjects and compare the values with non diabetic individuals and also to assess the correlation analysis between the biochemical parameters in type 2 DM subjects. Study Design: A case control study. Place and Duration of Study: Study was carried out from June 2012 to June 2013 in Bapuji Hospital and Chigateri General Hospital, Davangere, Karnataka, India. Methodology: A total of 87 subjects were included in the present study of which 56 type 2 Diabetes Mellitus patients and 31 control subjects. FPG, serum ferritin, HbA1c and serum nitric oxide were estimated in all subjects. Results: Intergroup comparison of biochemical parameters was done by unpaired “t” test and correlation between the parameters by Pearson’s coefficient analysis. The estimated mean levels (mean SEM) of FPG, serum ferritin, HbA1c and serum nitric oxide in control group were 98.06±1.30, 84.6±6.61, 5.46±0.15 and 39.0±0.84 respectively. Similarly, in type 2 diabetic patients mean levels of 179.5±7.11, 457.9±53.7, 9.49±0.25, and 100.9±3.5 were obtained for respective parameters. Mean values of all parameters were found to be significantly increased In DM subjects (P=.001) when compared to control group. Moreover, Serum ferritin has shown significant positive correlation with HbA1c and serum nitric oxide in type 2 DM patients with ‘P’ value of .05. Conclusion: The present study suggests that iron over load is one of the major factors in the pathogenesis of type 2 DM. Decreasing iron stores may reduce the oxidative stress, improve the vascular endothelial dysfunction and also improves insulin sensitivity in type 2 DM subjects.